Five Immunoassays Detecting Techniques
The five items of immunoassays mainly include the detection of immunoglobulin G, immunoglobulin A, immunoglobulin M, alexin C3 and alexin C4. The changes of immunoglobulin and alexin play a vital role in the occurrence and progression of kidney disease. The detection of immunoglobulin and alexin in patients’ peripheral Blood means a lot for understanding the body’s immune state, study its pathogenesis, impart the advice to the application of immunomodulator in clinic and the prognosis.
Normally speaking, the content of immunoglobulin G in umbilical cord blood is 7.6-17g/L, different ages have different indexes. When the level of immunoglobulin G increases, it may signal certain disease from occurring; they are chronic liver disease, infection, connective tissue disease and so on. On the contrary, when it reduces, diseases such as nephritic syndrome, and receiving immunosuppressive agent therapy etc would happen.
The level of immunoglobulin A will elevate as the patients suffer from autoimmune disease (for example, SLE and rheumatoid arthritis etc.), IgA nephropathy (or called berger’s disease) and so on.
The rise of immunoglobulin M occurs in people with liver disease, chronic infection and macroglobulinemia etc. it drops when one has burn, immunodepression, and some other diseases.
Under normal condition, C3 (β1C-globulin) in blood is 800-1550mg/L, the content of C4(β1E- globulin) is 130-370 mg/L. The alexin content and activity in blood will change under certain pathological mechanism. The increase of alexin is often caused by acute myocardium infarction, diabetes and acute gout etc.
The glomerular damage degree can be told by detecting the immunoglobulin B in serum, thus, it can provide the reference point for clinical treatment. Immunoglobulin A is the major immune globulin in secretion, it is important in local immunity. The increase of immunoglobulin A can mediate the occurrence of acute nephritis caused by the immune and inflammatory response. It helps tell the damage severity of glomeruli.
The levels of C3 and C4 lower among those active immune complexes nephrosis, for example, lupus nephritis. Due to C3 and C4 belong to acute phase protein, they rise as systemic infections, rheumatic fever, dermatomyositis, myocardial infarction, serious trauma and pregnancy develop. The level of alexin has definite guidance function to clinical treatment; what’s more, it is one important diagnostic criterion for the prognosis of kidney disease.
tag: Kidney disease treatment diagnosis lab tests
Previous：Special Tests for Kidney Disease in SKDH
next：How to Treat Lupus Nephritis in SKDH