Membranous Nephropathy refers to a kidney disorder which results in the inflammation and thickening of glomeruli. The glomeruli are the small blood vessels in the kidneys accounting for filtering wastes and fluids. Membranous nephropathy is one of the most common causes of Nephrotic Syndrome.
While, what cause the disease? As I just mentioned, the disease is caused by thickening of part of glomerular basement membrane, but exact reason for thickening is unknown. To be more specific, the thickening is triggered by large amount of immune complexes deposition. The Membranous Nephropathy, to put it another way, is one of the immune diseases and of course, could be treated with Immunotherapy (know about how, click here).
What about the symptoms of MN?
Due to the damages occur in the part of glomerular basement membrane leading to the parts fail to function normally or properly. Therefore, large amount of protein leakage shows up and becomes one of the first signs of MN.
Blood in urine which can be seen by naked eyes, this is the very first symptom for 80% of pediatric patients with IgA Nephropathy. Other symptoms are swelling, fatigue, foamy or bubble urine (due to the protein leakage), blood in urine, poor appetite, frequent urination at night and weight gaining etc.
The risk factors of this disease are list as followings:
Nephrotoxic toxins, including certain drugs and heavy metals
Infections could become the culprit of Membranous Nephropathy
Autoimmune diseases, for example, SLE, rheumatoid arthritis and other autoimmune disorders
It occurs commonly in people around 40 years old
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