Lupus and Lupus Nephritis: Causes and Treatments

Lupus or SLE (Systemic Lupus Erythemotosus) is a kind of chronic inflammatory disease. To be more specific, the disease is an immune disease caused by one’s own immune system attacking one’s own systems or organs. It affects multiple organs such as skin, nervous system, joint, lungs or heart. Of course, it attacks kidneys causing Lupus Nephritis, also known as lupus Kidney Disease by most people.

How lupus happens?

Healthy immune system produces antibodies to fight against foreign matters such as virus, bacteria or other infections so as to keep people healthy. However, people with lupus often have an abnormal immune system, meaning the antibodies can’t tell foreign substances from one’s own healthy cells, tissues and organs. Consequently, those antibodies attack its own body parts resulting in the occurrence of SLE.

About 1 in 3 people with lupus will suffer from Kidney Disease called Lupus Nephritis. In cases of lupus, antibodies couldn’t fight against antigens forming immune complexes. Those immune complexes easily deposited in kidneys since kidneys have binding epitope which is the perfect place for immune complex. Once the foreign matters deposit in kidneys, inflammatory reaction develops spontaneously to clear them out. Those complexes are hardly to be removed because they not only travel through the blood stream, but also lodge in kidneys. The inflammatory response won’t stop as long as those complexes lingering here. Overactive reaction impairs healthy cells, tissues and organs and account for Lupus Nephritis.

How to treat Lupus Nephritis?

People with lupus Kidney Disease often feel nothing different, since they don’t even have a clue that the SLE affected their kidneys. However, kidney damage can be a spell of mortality. So it is needed to be treated immediately. To those with mild Kidney Disease, lifestyle modification is necessary. Paying extra attention to the diet and staying away from salty foods is vital to stop the progression of Lupus Nephritis. Visiting doctor from time to time helps too. Renal biopsy may help diagnose Lupus Nephritis and then contributes to the prognosis. Taking control of blood pressure could slow down the progression too. Immunosuppressants are often prescribed when the Lupus Nephritis attacks seriously.

Our treatments are proven to be more effective than the immunosuppressants and other therapies, which is plasma exchange. It works for Lupus Nephritis patients with more noticeable therapeutic effects. More importantly, Lupus kidney disease and Lupus will be treated together in our hospital because lupus is the primary cause as well as root cause. As long as the primary disease is corrected, the inflammatory reaction is stopped and further renal damage can be suppressed accordingly.

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